Drug Guide
The full drug reference, loaded right here in a window: look up any drug's monograph, dosing, interactions and side effects without leaving this page. Below it, a second tool searches the FDA-approved package insert directly.
The window is DailyMed, the National Library of Medicine's official database of FDA drug labeling. Search any drug there without leaving this page. If it does not load in your browser, open it in its own tab, or use Drugs.com Professional, which no longer permits embedding.
Search the FDA label directly
Results are the manufacturer's FDA-approved package insert, served by the openFDA drug labeling API, with name matching by the National Library of Medicine's RxNav. It is the same text as the printed insert. That makes it authoritative on approved indications and dosing, and it also means it will not tell you about common off-label use, and it can lag behind current practice. For a curated clinical monograph, Drugs.com Professional is still worth a look, and there is a mobile edition.
Dosing principles worth knowing without looking up
Most package inserts specify adjustments by creatinine clearance rather than eGFR, so use the Cockcroft-Gault calculator. The common cutoffs are 50 and 30 mL/min. Remember that in acute kidney injury every equation overestimates function, because the creatinine has not caught up.
A loading dose depends on volume of distribution, not on clearance, so it usually does not change in renal failure. The maintenance dose is what you reduce. Giving a reduced load in a septic patient is a common and consequential error, particularly with vancomycin.
Know which weight the drug uses. Enoxaparin uses actual body weight. Aminoglycosides use adjusted body weight in obesity. Ventilator tidal volumes use ideal body weight. Getting the wrong weight into the right formula is one of the more common prescribing errors.
Before you add a second or third QT-prolonging agent, check a QTc and correct the potassium and magnesium. Fluoroquinolones, macrolides, azoles, ondansetron, haloperidol, methadone and amiodarone are the usual suspects, and inpatients accumulate them quickly.
Not the exotic ones the software flags fifty times a day. It is warfarin plus almost any antibiotic, statins plus azoles or macrolides, and anything serotonergic stacked on anything else serotonergic. If you override an interaction alert, know which of these three you are overriding.
Related on this site
For empiric antibiotic selection, the antibiotic coverage tables show which drugs cover which organisms. For the doses that come up overnight, see common night calls. For renal, hepatic and cardiac calculations, see the clinical calculators.
Verify every dose before you give it. This tool displays third-party data and may be incomplete, out of date, or unavailable. It does not know your patient's renal function, allergies or other medications. Always confirm against your institution's formulary and your pharmacist.